junctional diversity造句

• Although immunoglobulin junctional diversity is impaired, these individuals do not show a recognizable immunological phenotype.
• The coding ends are processed further prior to their ligation by several events that ultimately lead to junctional diversity.
• TdT is absent in fetal liver HSCs, significantly impairing junctional diversity in B-cells during the fetal period.
• The inaccuracies of joining provided by junctional diversity is estimated to triple the diversity initially generated by these V ( D ) J recombinations.
• Mutations play a part in both normal and abnormal biological processes including : evolution, cancer, and the development of the immune system, including junctional diversity.
• "' Junctional diversity "'describes the DNA sequence variations introduced by the improper joining of gene segments during the process of V ( D ) J recombination.
• Generation of junctional diversity starts as the proteins, recombination activating gene-1 and-2 ( RAG1 and RAG2 ), along with DNA repair proteins, such as repair machinery.
• Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes.